IJPAM: Volume 31, No. 1 (2006)

A PARAMETER SEARCH ALGORITHM BASED
ON OPTIMAL LINEAR CODES

Gregory M. Constantine$^{1}$, John Bartels$^2$, Marius Buliga$^{3}$,
Gilles Clermont$^4$, Yoram Vodovotz$^5$
$^{1}$Department of Mathematics
University of Pittsburgh
Pittsburgh, PA 15260, USA
e-mail: gmc@euler.math.pitt.edu
$^2$Immunetrics, Inc.
Pittsburgh, PA 15260, USA
$^{3}$Department of Mathematics
University of Pittsburgh-Bradford
Bradford, PA 16701, USA
e-mail: buliga@pitt.edu
$^4$Department of Critical Care Medicine
University of Pittsburgh Medical Center
Pittsburgh, PA 15260, USA
$^5$ Department of Surgery
University of Pittsburgh Medical Center
Pittsburgh, PA 15260, USA


Abstract.Modeling by way of dynamical systems often leads to systems of ordinary differential equations involving a large number of parameters, such as growth rates and initial conditions. A parameter search algorithm based on optimal linear codes is developed having as aim the identification of different regimes of behaviour of the model and its calibration to data.

Received: June 7, 2006

AMS Subject Classification: 68R01, 37M05

Key Words and Phrases: optimization, differential equations, immune system, mathematical modeling

Source: International Journal of Pure and Applied Mathematics
ISSN: 1311-8080
Year: 2006
Volume: 31
Issue: 1