IJPAM: Volume 71, No. 3 (2011)

COMBINATIONS OF DRUGS
THAT PRODUCE OPPOSITE EFFECTS

Ronald J. Tallarida$^1$, Neil S. Lamarre$^2$, Khalid Benamar$^3$
$^{1,2,3}$Department of Pharmacology and Center
for Substance Abuse Research
School of Medicine
Temple University
Philadelphia, PA 19140, USA


Abstract. Numerous studies have examined combinations of drugs that produce overtly similar effects in order to determine whether such combinations produce unusual interactions indicating synergism. When two drugs, or a drug and an endogenous chemical, individually produce opposite effects there is equal interest in the quantitative assessment of interactions in these combinations. This case of opposing effects, not previously examined quantitatively, is the subject of this communication.

Received: May 25, 2011

AMS Subject Classification: 92C45, 92C60

Key Words and Phrases: isobole, synergism, dose equivalence, drug additivity, sub-additivity, dose-effect relation, delta method, morphine, cannabinoid, body temperature

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Source: International Journal of Pure and Applied Mathematics
ISSN printed version: 1311-8080
ISSN on-line version: 1314-3395
Year: 2011
Volume: 71
Issue: 3