IJPAM: Volume 82, No. 1 (2013)
STRUCTURE IN PHYSIOLOGICALLY BASED
PHARMACOKINETIC (PBPK) MODELING
OF INHALED TOXICANTS
Department of Mathematics and Statistics
Elon, NC 27244, USA
Abstract. Physiologically based pharmacokinetic (PBPK) models translate external concentrations into internal dose estimates. Most PBPK models use multiple assumptions when modeling toxicant uptake through ventilation. This study uses existing human PBPK models of xylene and perchloroethylene to investigate the effect of the structure of air and blood concentration equations on compartmental predictions. Differences in ventilation equation structure do have an effect on model predictions and may affect parameter estimates found through inverse problems.
Received: October 8, 2012
AMS Subject Classification: 92B05
Key Words and Phrases: PBPK, xylene, perchloroethylene
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Source: International Journal of Pure and Applied Mathematics
ISSN printed version: 1311-8080
ISSN on-line version: 1314-3395